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Our Pipeline

Pipeline icon

Leading the Way in Cell Therapy

Our pipeline of cancer therapies in the areas of cell therapy, immuno-oncology, and targeted therapies includes investigational therapies and next-generation technologies that have the power to transform the way cancer is treated. As we look to the future, we remain focused on advancing technologies that could someday address additional hematological malignancies and solid tumors.

PROGRAM

PHASE

  • PHASE 1
  • PHASE 2
  • PHASE 3
  • NDA / BLA / MAA

Tecartus® (brexu-cel)1

  • BLA / MAA

Trial:

ZUMA-2

 

Mantle cell lymphoma

Yescarta® (axi-cel)2

  • BLA

Trial:

ZUMA-5

 

Indolent non-Hodgkin's lymphoma

Yescarta® (axi-cel)

  • PHASE 3

Trial:

ZUMA-7

 

2L Diffuse large B cell lymphoma

Yescarta® (axi-cel)

  • PHASE 2

Trial:

ZUMA-12

 

1L Diffuse large B cell lymphoma

Yescarta® (axi-cel)3

  • PHASE 2

Trial:

ZUMA-14

 

3L Diffuse large B cell lymphoma (+rituximab)

Brexu-cel2

  • PHASE 2

Trial:

ZUMA-3

 

Adult acute lymphocytic leukemia

Brexu-cel2

  • PHASE 2

Trial:

ZUMA-4

 

Pediatric acute lymphocytic leukemia and pediatric non-Hodgkin's lymphoma

Yescarta® (axi-cel)4

  • PHASE 1

Trial:

ZUMA-19

 

3L Diffuse large B cell lymphoma (+lenzilumab)

Brexu-cel

  • PHASE 1

Trial:

ZUMA-8

 

Chronic lymphocytic leukemia

Yescarta® (axi-cel)5

  • PHASE 1

Trial:

ZUMA-11

 

3L Diffuse large B cell lymphoma (+utomilumab)

KITE-718 (MAGE-A3/A6)6

  • PHASE 1

Trial:

N/A

 

Solid tumors

KITE-439 (HPV-16 E7)6

  • PHASE 1

Trial:

N/A

 

Solid tumors

1 Conditional approvals.
2 Breakthrough therapy designation.
3 Clinical collaboration with Genentech.
4 Clinical collaboration with Humanigen.
5 Clinical collaboration with Pfizer.
6 Collaboration with NIH.

Axi-cel - Axicabtagene ciloleucel.
Brexu-cel - Brexucabtagene autoleucel.

The safety and efficacy of these investigational agents or investigational uses of marketed products have not been established. These uses have not been approved by the US Food and Drug Administration or other regulatory authorities. There is no guarantee that these therapies or uses will be commercialized.

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